A framework for counting alleles in computational clouds
DOI:
https://doi.org/10.59681/2175-4411.v16.iEspecial.2024.1312Keywords:
Big Data, Computational Clouds, HLA allelesAbstract
Objective: develop a framework to carry out anthropological comparisons, classify alleles, infer the waiting time of patients requiring transplantation, among other analyses. Method: comparison of donor and patient alleles using a search algorithm to, based on allele counts, perform analysis. To reduce analysis execution time, queries were optimized and parallelized, allowing their efficient execution in computing clouds. Results: the framework is capable of performing analysis in seconds, even on a database that contains more than 5 million records. Conclusion: the proposed framework has the potential to help clinicians/researchers obtain information to improve the organ donation process among unrelated donors.
References
Singh AK, McGuirk JP. Allogeneic Stem Cell Transplantation: A Historical and Scientific Overview. Cancer Research (2016) 76:6445-6451.
Tiercy JM. How to select the best available related or unrelated donor of hematopoietic stem cells? Haematologica (2016) 101(6):680-687.
Gragert L. et al. HLA match likelihoods for hematopoietic stem-cell grafts in the U.S. registry. New England Journal of Medicine, 2014, 371(4):339-348.
Burns LJ, Miller JP, Confer DL. Past, present and future of the national marrow donor program. Revista de Hematología. 2016;17(3):195-204.
Dehn J. et al. HapLogic: A predictive human leukocyte antigen matching algorithm to enhance rapid identification of optimal unrelated hematopoietic stem cell sources for transplantation. Biology of Blood and Marrow Transplantation. 2016, 22(11):2038-2046.
Bochtler, W. et al. A Comparative Reference Study for the Validation of HLA-Matching Algorithms in the Search for Allogeneic Hematopoietic Stem Cell donors and cord blood units. HLA. 2016, 87(6).
Marcio N. P. Silva, Karla Figueiredo, Luís C. M. S. Pôrto, Alexandre C. Sena. Uma Abordagem para Análise de Padrões em Banco de Dados de Doadores de Órgãos. Anais do Simpósio Brasileiro de Computação Aplicado a Saúde. 2022.
Lancaster AK, Single RM, et al. PyPop: A mature open-source software pipeline for population genomics. Frontiers in Immunology. 2024, 15.
Excoffier L, Lischer HE. Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Mol Ecol Resour. 2010, 10(3):564-567.
Nunes K, Aguiar V, Silva M. et al. How Ancestry Influences the Chances of Finding Unrelated Donors: An Investigation in Admixed Brazilians. Frontiers in Immunology. 2020, 11.
REDOME - Registro Nacional de Doadores Voluntários de Medula Óssea. 2024.
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