Analysis of the Prevalence of HLA Alleles in Patients with COVID-19
DOI:
https://doi.org/10.59681/2175-4411.v15.iEspecial.2023.1083Keywords:
Case-Control Study, HLA alleles, Matching AlgorithmAbstract
The aim of this work was to analyze the prevalence of HLA alleles in patients with COVID-19 through a Case-Control Study (CCS). The methodology used the information systems SIVEP-Gripe, which records cases of Severe Acute Respiratory Syndrome (SARS), and e-SUS, which records suspected or confirmed cases of COVID-19, to compose the database for the CCS. Then, a query was performed on the organ donor database (REDOME) to obtain the HLA alleles. To obtain a homogeneous control base for the CCS from the characteristics of the case base records, a matching algorithm was implemented. Finally, the analysis of the HLA alleles in patients with COVID-19 was performed. The results show the balanced choice of the algorithm and the allele analysis showed differences between the distribution of allelic groups as a function of ethnicity/race.
References
Brasil, Ministério da Sáude. e-SUS Notifica [Internet]. Available from: https://www.gov.br/saude/pt-br/composicao/svs/sistemas-de-informacao/e-sus-notifica
Brasil, Ministério da Sáude. SIVEP-Gripe [Internet]. Available from: https://sivepgripe.saude.gov.br/sivepgripe/
Correale P, Mutti L, Pentimalli F, et al. HLA-B*44 and C*01 Prevalence Correlates with Covid19 Spreading across Italy. Int J Mol Sci. 2020; 21(15).
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Copyright (c) 2023 Gabriel P. Mendes, Luís C. M. S. Pôrto, Cristiano Lima, Helton Santiago, Stephanie Almeida, Alexandre C. Sena
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